First off, Im going to start with the new game coming out soon, Duke Nukem Forever. Now, I'm a HUGE fan of the Duke Nukem series so when I saw the trailer, I went crazy. The game play looks fantastic (see video) and the Duke's quotes are still in, making way for a memorable experience.
The introduction of vehicles should be a new twist, along with the new "pickup one weapon, drop another" style of play, rather than the series' old Doom like ways of holding everything you picked up. Another introduction is having to reload weapons, whereas in the old games you could fire forever (as long as you had ammo, that is).
The biggest thing to mention is that the whole world seems to be interactive. From what I've seen, you can write on white boards, use urinals, turn on/off sinks, valves, etc. and even kick a field goal with a dead boss' eye. The best thing is though some of the aforementioned 'interactions' may seem pointless, there is a high chance they will be used to uncover power-ups or powerful weapons like in previous games.
Overall, this looks like an exciting game, and like many other Duke fans, I cant wait to play it, as it should be really good. But of course, "after 12 f***ing years it should be".
Without any further adieu...